SAFETY INFORMATION

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT NEXIUM?

NEXIUM may help your acid-related symptoms, but you could still have serious stomach problems. Talk with your doctor. NEXIUM can cause serious side effects, including:

  • Diarrhea. NEXIUM may increase your risk of getting severe diarrhea. This diarrhea may be caused by an infection (Clostridium difficile) in your intestines

    Call your doctor right away if you have watery stool, stomach pain, and fever that does not go away.
  • Bone fractures. People who take multiple daily doses of proton pump inhibitor medicines for a long period of time (a year or longer) may have an increased risk of fractures of the hip, wrist, or spine. You should take NEXIUM exactly as prescribed, at the lowest dose possible for your treatment and for the shortest time needed. Talk to your doctor about your risk of bone fracture if you take NEXIUM
WHO SHOULD TAKE NEXIUM?
Do not take NEXIUM if you:
  • are allergic to esomeprazole magnesium or any of the ingredients in NEXIUM. See the Medication GuidePDF Icon
    for a complete list of ingredients in NEXIUM
  • are allergic to any other proton pump inhibitor (PPI) medicine
WHAT SHOULD I TELL MY DOCTOR BEFORE I TAKE NEXIUM?
Before you take NEXIUM, tell your doctor if you:
  • have been told that you have low magnesium levels in your blood
  • have liver problems
  • are pregnant or plan to become pregnant. It is not known if NEXIUM can harm your unborn baby
  • are breastfeeding or planning to breastfeed. It is not known if NEXIUM passes into your breastmilk. You and your doctor should decide if you will take NEXIUM or breastfeed. You should not do both. Talk to your doctor about the best way to feed your baby if you take NEXIUM
Tell your doctor about all of the medicines you take

including prescription and non-prescription drugs, vitamins and herbal supplements. NEXIUM may affect how other medicines work, and other medicines may affect how NEXIUM works. Especially tell your doctor if you take:

  • warfarin (Coumadin, Jantoven)
  • ketoconazole (Nizoral)
  • voriconazole (Vfend)
  • atazanavir (Reyataz)
  • nelfinavir (Viracept)
  • saquinavir (Fortovase)
  • products that contain iron
  • digoxin (Lanoxin)
  • St. John’s Wort (Hypericum perforatum)
  • Rifampin (Rimactane, Rifater, Rifamate)
  • cilostazol (Pletal)
  • diazepam (Valium)
  • tacrolimus (Prograf)
  • erlotinib (Tarceva)
  • methotrexate
  • clopidogrel (Plavix)
WHAT ARE THE POSSIBLE SIDE EFFECTS OF NEXIUM?
NEXIUM can cause serious side effects, including:
  • Chronic (lasting a long time) inflammation of the stomach lining (Atrophic Gastritis). Using NEXIUM for a long period of time may increase the risk of inflammation to your stomach lining. You may or may not have symptoms. Tell your doctor if you have stomach pain, nausea, vomiting, or weight loss
  • Low magnesium levels in your body. This problem can be serious. Low magnesium can happen in some people who take a proton pump inhibitor medicine for at least 3 months. If low magnesium levels happen, it is usually after a year of treatment. You may or may not have symptoms of low magnesium

Tell your doctor right away if you have any of these symptoms:

  • seizures
  • dizziness
  • abnormal or fast heartbeat
  • jitteriness
  • jerking movements or shaking (tremors)
  • muscle weakness
  • spasms of the hands and feet
  • cramps or muscle aches
  • spasm of the voice box

Your doctor may check the level of magnesium in your body before you start taking NEXIUM or during treatment if you will be taking NEXIUM for a long period of time.

The most common side effects with NEXIUM may include:

  • headache
  • diarrhea
  • nausea
  • gas
  • abdominal pain
  • constipation
  • dry mouth
  • drowsiness

Other side effects:

Serious allergic reactions.

Tell your doctor if you get any of the following symptoms with NEXIUM:

  • rash
  • face swelling
  • throat tightness
  • difficulty breathing

Your doctor may stop NEXIUM if these symptoms happen.

Tell your doctor if you have any side effects that bother you or that do not go away. These are not all the possible side effects with NEXIUM.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Remember, if you have any questions about your treatment with NEXIUM, talk with your doctor.

YOUR BRAND. YOUR CHOICE.

SEARCH THE FAQs

about NEXIUM and more

HOW TO TAKE NEXIUM

to relieve persistent heartburn caused by acid reflux disease

Important Safety Information About NEXIUM

  • Symptom relief does not rule out the presence of other serious stomach conditions
  • NEXIUM may increase your risk of getting severe diarrhea. Call your doctor right away if you have watery stool, stomach pain and fever that does not go away
  • Talk to your doctor about your risk for:
    • bone fractures if you take multiple daily doses of NEXIUM for a long period of time
    • low magnesium levels if you take NEXIUM for a long period of time
  • Tell your doctor about all of the medicines you take, prescription and non-prescription drugs, including clopidogrel, vitamins and herbal supplements. NEXIUM may affect how other medicines work and other medicines may affect how NEXIUM works
  • Side effects with NEXIUM include headache, diarrhea, and abdominal pain

Approved Uses for NEXIUM

NEXIUM is prescribed to treat the symptoms of acid reflux disease, which typically include persistent heartburn on 2 or more days per week, despite treatment and change of diet.

For many people, NEXIUM is also prescribed to heal damage to the esophagus called erosive esophagitis. This damage may be caused over time from stomach acid wearing away the lining of the esophagus. Only a doctor can diagnose this condition. With NEXIUM, most erosions heal in 4 to 8 weeks. Your results with NEXIUM may vary.

Please see full Prescribing Information.PDF Icon
Please see Medication Guide.PDF Icon