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WHAT CAUSES
ACID REFLUX DISEASE

Acid Backup

A faulty valve

The main cause of acid reflux disease is a problem with the lower esophageal sphincter (LES) muscle. This muscle, which is the “valve” between the stomach and the esophagus, normally closes tightly after food has passed through to the stomach.

The LES does not stay closed in people with acid reflux disease. When this happens, acid and stomach contents may back up (reflux) into the esophagus. This acid backup can sometimes cause the painful, burning sensation known as heartburn or other symptoms.

Lifestyle factors to consider

There are lifestyle factors that can make heartburn worse. Some of these include:

  • Being overweight
  • Smoking
  • Stress
  • Eating too much food at one time
  • Wearing tight clothing that puts pressure on your stomach

Trigger foods to avoid

Certain foods can trigger heartburn symptoms
associated with acid reflux. Foods to avoid include:

  • Spicy, fried, or fatty foods
  • Tomato-based foods such as pizza,
    pasta sauce, and salsa
  • Citrus fruits and juices
  • Onions and garlic
  • Chocolate
  • Mint flavorings
  • Caffeinated and alcoholic drinks
  • Coffee and tea (caffeinated or decaffeinated)
  • Soda and other carbonated drinks

YOUR BRAND. YOUR CHOICE.

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Important Safety Information About NEXIUM

  • Symptom relief does not rule out the presence of other serious conditions. Talk with your doctor
  • Talk to your doctor about serious side effects, including:

    • Kidney problems (acute interstitial nephritis) may happen at any time during treatment with NEXIUM. Call your doctor if you have a decrease in the amount that you urinate or if you have blood in your urine
    • NEXIUM may increase your risk of getting severe diarrhea. Call your doctor right away if you have watery stool, stomach pain and fever that does not go away
    • Bone fractures if you take multiple daily doses of NEXIUM for a year or longer
    • Some people who take PPIs, including NEXIUM, develop certain types of lupus or have worsening of the lupus they already have. Call your doctor right away if you have joint pain or rash on your cheeks or arms that gets worse in the sun
    • Low vitamin B12 if you have been on NEXIUM for a long time (more than 3 years)
    • Low magnesium levels if you take NEXIUM (for 3 months or more)
  • Tell your doctor about all of the medicines you take, prescription and nonprescription drugs, including clopidogrel, vitamins and herbal supplements. NEXIUM may affect how other medicines work and other medicines may affect how NEXIUM works
  • Do not take NEXIUM if you are allergic to esomeprazole magnesium or any of the ingredients in NEXIUM or are allergic to any other PPI
  • Side effects with NEXIUM may include headache, diarrhea, and abdominal pain

Approved Uses for NEXIUM

NEXIUM is prescribed to treat the symptoms of acid reflux disease, which typically include persistent heartburn on 2 or more days per week, despite treatment and change of diet.

For many people, NEXIUM is also prescribed to heal damage to the esophagus called erosive esophagitis. This damage may be caused over time from stomach acid wearing away the lining of the esophagus. Only a doctor can diagnose this condition. With NEXIUM, most erosions heal in 4 to 8 weeks. Your results with NEXIUM may vary.

Please see full Prescribing Information.PDF Icon
Please see Medication Guide.PDF Icon

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

The information on this Web site should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about NEXIUM, talk to your doctor or pharmacist. Only you and your health care professional can decide if NEXIUM is right for you.

If you have any questions or would like additional information, please contact AstraZeneca at 1-800-236-9933, Monday through Friday, 8 AM to 6 PM ET, excluding holidays.