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Questions? We’ve got answers.

Do you have additional questions?

We’re here to help you by e-mail, chat, or by calling 1-800-4-NEXIUM.



Why choose NEXIUM Direct?

NEXIUM Direct is an easy way to get prescription NEXIUM delivered right to your mailbox. NEXIUM Direct includes 24-hour support, automatic refills, free home delivery, and we work directly with your insurance company. You will pay no more than what you pay at the pharmacy (see savings chart).

What is automatic refill?

When you elect for automatic refill, your medication will be automatically shipped to your home each month and charged to your credit card on file. You may cancel automatic refills at any time.

When will I receive my NEXIUM?

For your initial order, you should receive your prescription NEXIUM 7-10 days after enrolling in NEXIUM Direct. Refills usually ship within 1-2 business days after processing.

Am I eligible for NEXIUM Direct?

Patients with a valid prescription for NEXIUM are eligible for the NEXIUM Direct program, including patients with prescription insurance coverage and patients without insurance.

Who are AstraZeneca and Eagle Pharmacy?

AstraZeneca is the maker of NEXIUM. Our NEXIUM Direct program is operated by AstraZeneca Direct, a program that delivers brand-name medications directly to patients. Prescriptions are processed and handled by Eagle Pharmacy, our trusted pharmacy administrator.


Does NEXIUM Direct accept commercial insurance?

Yes. Patients whose co-pay is $140 or less for a 30-day supply will pay $15. Patients with a co-pay over $140 will receive a $125 discount.

What if I’m uninsured or my insurance doesn’t cover prescription NEXIUM?

If you’re uninsured or your insurance doesn’t cover NEXIUM, you can receive a $50 contribution to the total cash price for NEXIUM. Please call 1-800-4-NEXIUM for more information.

Does the NEXIUM Direct program accept Medicare Part D, Medicaid, or other federal programs?

NEXIUM Direct is not available for prescriptions purchased under Medicaid or other similar state or federal government programs (eg, TriCare, Department of Defense, Veterans Affairs). Patients with Medicare Part D coverage are able to participate in the program and receive patient support services, but are not eligible to receive the NEXIUM Savings Card offer and will pay the co-pay according to their plan.

Still have questions? Call 1-800-4-NEXIUM.


How much will you save?




Important Safety Information

  • Symptom relief does not rule out the presence of other serious conditions. Talk with your doctor
  • Talk to your doctor about serious side effects, including:

    • Kidney problems (acute interstitial nephritis) may happen at any time during treatment with NEXIUM. Call your doctor if you have a decrease in the amount that you urinate or if you have blood in your urine
    • NEXIUM may increase your risk of getting severe diarrhea. Call your doctor right away if you have watery stool, stomach pain and fever that does not go away
    • Bone fractures if you take multiple daily doses of NEXIUM for a year or longer
    • Some people who take PPIs, including NEXIUM, develop certain types of lupus or have worsening of the lupus they already have. Call your doctor right away if you have joint pain or rash on your cheeks or arms that gets worse in the sun
    • Low vitamin B12 if you have been on NEXIUM for a long time (more than 3 years)
    • Low magnesium levels if you take NEXIUM (for 3 months or more)
  • Tell your doctor about all of the medicines you take, prescription and nonprescription drugs, including clopidogrel, vitamins and herbal supplements. NEXIUM may affect how other medicines work and other medicines may affect how NEXIUM works
  • Do not take NEXIUM if you are allergic to esomeprazole magnesium or any of the ingredients in NEXIUM or are allergic to any other PPI
  • Side effects with NEXIUM may include headache, diarrhea, and abdominal pain

Approved Uses for NEXIUM

NEXIUM is prescribed to treat the symptoms of acid reflux disease, which typically include persistent heartburn on 2 or more days per week, despite treatment and change of diet.

For many people, NEXIUM is also prescribed to heal damage to the esophagus called erosive esophagitis. This damage may be caused over time from stomach acid wearing away the lining of the esophagus. Only a doctor can diagnose this condition. With NEXIUM, most erosions heal in 4 to 8 weeks. Your results with NEXIUM may vary.

Please see full Prescribing Information.PDF Icon

The information on this Web site should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about NEXIUM, talk to your doctor or pharmacist. Only you and your health care professional can decide if NEXIUM is right for you.

If you have any questions or would like additional information, please contact AstraZeneca at 1-800-236-9933, Monday through Friday, 8 AM to 6 PM ET, excluding holidays.