PROVEN HEALING OF EE

In all pivotal trials of NEXIUM 40 mg in the healing of erosive esophagitis (EE)

92%–94% of patients with erosive esophagitis (EE) healed—that's the efficacy of NEXIUM 40 mg

HEALING vs OMEPRAZOLE

Healing-Vs-OmeprazoleHealing-Vs-Omeprazole

In gastroesophageal reflux disease (GERD) patients with varying grades of EE[a] through 8 weeks,[1-3],[b] 94% of patients were healed with NEXIUM 40 mg QD (n=1216) vs 84% with omeprazole 20 mg QD (n=1209) (P<.001).[1],[2]

In gastroesophageal reflux disease (GERD) patients with varying grades of EE[a] through 8 weeks,[1-3],[b] 94% of patients were healed with NEXIUM 40 mg QD (n=654) and 90% of patients were healed with NEXIUM 20 mg QD (n=656) vs 87% with omeprazole 20 mg QD (n=650) (P value, 40 mg: P<.001; 20 mg: P<.05).[1],[3]

  • In another study, 92% of patients were healed with NEXIUM 40 mg QD (n=576) vs 90% with omeprazole 20 mg QD (n=572) (P=Not Significant(NS))[4],[b]
  • In an additional study with NEXIUM 20 mg (n=587), 91% of the patients on NEXIUM 20 mg were healed compared to 88% of the patients on omeprazole 20 mg (n=588) (P=NS)[5],[b]
  • a ^ Varying grades of EE defined as LA grades A, B, C, and D.[2],[3]
  • b ^ Data from multicenter, randomized, double-blind trials comparing oral doses of NEXIUM vs omeprazole, administered once-daily to patients with endoscopically diagnosed EE.[1-5]

NEXIUM 40 mg, NEXIUM 20 mg, and omeprazole 20 mg are the FDA-approved doses for the healing of EE.

HEALING vs LANSOPRAZOLE

Healing-Vs-Lansoprazole Healing-Vs-Lansoprazole

In GERD patients with varying grades of EE[c] through 8 weeks,[6],[d] 93% of patients were healed with NEXIUM 40 mg QD (n=2624) vs 89% with omeprazole 30 mg QD (n=2617) (P=.0001).[6]

In GERD patients with moderate-to-severe EE[e] through 8 weeks,[7],[d] 82% of patients were healed with NEXIUM 40 mg QD (n=498) vs 78% with lansoprazole 30 mg QD (n=501) (P=.007).[7]

  • c ^ Varying grades of EE defined as LA grades A, B, C, and D.[6]
  • d ^ Primary endpoints from multicenter, randomized, double-blind, parallel-group, 8-week trials comparing oral doses of NEXIUM 40 mg vs lansoprazole 30 mg, administered once-daily to patients with endoscopically diagnosed EE.[6],[7]
  • e ^ Moderate-to-severe EE defined as LA grades C and D.[7]

NEXIUM 40 mg, NEXIUM 20 mg, and lansoprazole 30 mg are the FDA-approved doses for the healing of EE.

View symptom relief data